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Journal article

The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.

Abstract:

Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx). Recently, it has been proposed that the observed association of certain ER-directed toxins and viruses with detergent-resistant membranes (DRM) may provide a general mechanism for their retrograde transport to endoplasmic reticulum (ER). Here...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e05-11-1035

Authors


Sillence, DJ More by this author
Falguières, T More by this author
Jarvis, RM More by this author
Johannes, L More by this author
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Journal:
Molecular biology of the cell
Volume:
17
Issue:
3
Pages:
1375-1387
Publication date:
2006-03-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:5b77ea1c-26ec-440b-b11a-249d4976cafc
Source identifiers:
185140
Local pid:
pubs:185140

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