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Representation of multiple cellular phenotypes within tissue-level simulations of cardiac electrophysiology

Abstract:

Distinct electrophysiological phenotypes are exhibited by biological cells that have differentiated into particular cell types. The usual approach when simulating the cardiac electrophysiology of tissue that includes different cell types is to model the different cell types as occupying spatially distinct yet coupled regions. Instead, we model the electrophysiology of well-mixed cells by using homogenisation to derive an extension to the commonly used monodomain or bidomain equations. These ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1007/s11538-018-0516-1

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
MPLS Doctoral Training Centre
Mirams, GR More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Oxford college:
Linacre College
Publisher:
Springer Verlag Publisher's website
Journal:
Bulletin of Mathematical Biology Journal website
Volume:
81
Issue:
1
Pages:
7–38
Publication date:
2018-10-05
Acceptance date:
2018-06-20
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Pubs id:
pubs:859658
URN:
uri:5b735e1e-bcef-4d5a-9188-fcd4493c79eb
UUID:
uuid:5b735e1e-bcef-4d5a-9188-fcd4493c79eb
Local pid:
pubs:859658

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