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Journal article

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes

Abstract:

For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast). Paradoxically, during this disruption, new attachments are still formed efficiently to enable fresh attempts at bi-orientation. How this is possible remains an enigma. Here we show that kinetochore attachment to t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/ncb3128

Authors


Kalantzaki, M More by this author
Kitamura, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Cell Biology Journal website
Volume:
17
Issue:
4
Pages:
421-433
Publication date:
2015-03-05
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:5b5eb7e3-7532-4f67-babb-a7947b003f89
Source identifiers:
509988
Local pid:
pubs:509988
Language:
English

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