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The fatty acid synthase gene is a conserved p53 family target from worm to human.

Abstract:

The discovery that the p53 family consists of three members (p53, p63 and p73) in vertebrates and of a single homolog in invertebrates has raised the challenge of understanding the functions of the ancestor and how they have evolved and differentiated within the duplicated genes in vertebrates. Here, we report that the fatty acid synthase (FAS) gene, encoding for a key enzyme involved in the biogenesis of membrane lipids in rapidly proliferating cells, is a conserved target of the p53 family ...

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Publisher copy:
10.4161/cc.5.7.2622

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
5
Issue:
7
Pages:
750-758
Publication date:
2006-04-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:5b4e67c8-371a-49b8-a905-73725c612fdd
Source identifiers:
370043
Local pid:
pubs:370043

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