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Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-riming and boosting with adenovirus or protein based vaccines

Abstract:

There is a requirement for vaccines or vaccination strategies that confer better protection against TB than the current live attenuated Mycobacterium bovis Bacillus Calmette-Guerin (BCG) vaccine for use in cattle. Boosting with recombinant viral vectors expressing mycobacterial proteins, such as Ag85A, has shown a degree of promise as a strategy for improving on the protection afforded by BCG. Experiments in small animal models have indicated that broadening the immune response to include myc...

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Journal:
Vaccine
Volume:
32
Issue:
11
Pages:
1304-1310
Publication date:
2014-03-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:5b4a505d-314c-44f3-aca4-ce352d1a7abe
Source identifiers:
450187
Local pid:
pubs:450187

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