Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice.

Journal article

Antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRI) act as indirect agonists of serotonin (5-HT) receptors. Although these drugs produce a rapid blockade of serotonin transporters (SERTs) in vitro, several weeks of treatment are necessary to observe clinical benefits. This paradox has not been solved yet. Recent studies have identified modifications of intracellular signaling proteins and target genes that could contribute to antidepressant-like activity of SSRI (e.g., incr...

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Authors: Deltheil, T; Guiard, B; Cerdan, J; David, D; Tanaka, K

• Journal: Neuropharmacology
• Volume: 55
• Issue: 6
• Pages: 1006-1014
• Publication date: 2008-11-01
• DOI: 10.1016/j.neuropharm.2008.08.001
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Gene Expression Regulation; Mice, Knockout; Serotonin; Serotonin Agents; Behavior, Animal; Serotonin Plasma Membrane Transport Proteins; Brain-Derived Neurotrophic Factor; Mice; Brain Chemistry; Hippocampus; Animals