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Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Abstract:

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocali...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-07345-0

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Publication date:
2018-11-28
Acceptance date:
2018-10-29
DOI:
EISSN:
2041-1723
Pubs id:
pubs:944068
URN:
uri:5b356791-fc15-425d-99eb-2f2ad36d1c2c
UUID:
uuid:5b356791-fc15-425d-99eb-2f2ad36d1c2c
Local pid:
pubs:944068

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