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Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study.

Abstract:

BACKGROUND: The amygdala is a central node in the brain network that processes aversive emotions and is extensively innervated by dorsal raphe nucleus (DRN) serotonin (5-hydroxytryptamine [5-HT]) neurons. Alterations in DRN 5-HT1A receptor availability cause phenotypes characterized by fearful behavior in preclinical models. However, it is unknown whether 5-HT1A receptor availability is linked specifically to the processing of aversive emotions in humans or whether it modulates connectivity i...

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Publication status:
In press
Peer review status:
Peer reviewed

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Authors


Selvaraj, S More by this author
Mouchlianitis, E More by this author
Faulkner, P More by this author
Turkheimer, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Publisher:
Elsevier Publisher's website
Journal:
Biological psychiatry Journal website
Publication date:
2014
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:5b31a000-d39c-4663-97d7-912410f3ed54
Source identifiers:
469132
Local pid:
pubs:469132

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