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Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1

Abstract:

Horizontal gene transfer (HGT) mediated by the spread of plasmids fuels evolution in prokaryotes. Although plasmids provide bacteria with new adaptive genes, they also produce physiological alterations that often translate into a reduction in bacterial fitness. The fitness costs associated with plasmids represent an important limit to plasmid maintenance in bacterial communities, but their molecular origins remain largely unknown. In this work we combine phenomics, transcriptomics and metabol...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41396-018-0224-8

Authors


San Millan, A More by this author
Toll-Riera, M More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Chemistry Research Laboratory
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Funding agency for:
Hopkinson, RJ
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Funding agency for:
Maclean, RC
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Publisher:
Nature Publishing Group Publisher's website
Journal:
ISME Journal Journal website
Volume:
12
Issue:
12
Pages:
3014–3024
Publication date:
2018-08-10
Acceptance date:
2018-05-25
DOI:
EISSN:
1751-7370
ISSN:
1751-7362
Pubs id:
pubs:854281
URN:
uri:5b20c680-7a8a-4451-ac50-98f13fddf5b0
UUID:
uuid:5b20c680-7a8a-4451-ac50-98f13fddf5b0
Local pid:
pubs:854281

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