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Journal article

Temperature-dependent folding allows stable dimerization of secretory and virus-associated E proteins of Dengue and Zika viruses in mammalian cells

Abstract:

Dengue and Zika are two of the most important human viral pathogens worldwide. In both cases, the envelope glycoprotein E is the main target of the antibody response. Recently, new complex quaternary epitopes were identified which are the consequence of the arrangement of the antiparallel E dimers on the viral surface. Such epitopes can be exploited to develop more efficient cross-neutralizing vaccines. Here we describe a successful covalent stabilization of E dimers from Dengue and Zika viru...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-017-01097-5

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-0012-5247
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific reports Journal website
Volume:
7
Issue:
1
Pages:
14
Chapter number:
966
Publication date:
2017-04-19
Acceptance date:
2017-03-24
DOI:
EISSN:
2045-2322
Pubs id:
pubs:863434
URN:
uri:5b1c7065-65f8-4d9a-81e8-8f0067c9492a
UUID:
uuid:5b1c7065-65f8-4d9a-81e8-8f0067c9492a
Local pid:
pubs:863434

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