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Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.

Abstract:

OBJECTIVES: Our aim was to investigate mechanisms of inflammation-induced endothelial dysfunction in humans. METHODS: Endothelial function in twenty-one healthy human volunteers was measured using forearm venous plethysmography before and 8 h after administration of typhoid vaccination to generate an inflammatory response. Basal and stimulated endothelial nitric oxide (NO) bioavailability was assessed by measurement of the responses to intra-arterial N(G)-monomethyl-l-arginine (l-NMMA) and b...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
Cardiovascular research
Volume:
64
Issue:
1
Pages:
172-178
Publication date:
2004-10-01
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Source identifiers:
104924

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