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Thesis

Dynamics in the regulatory genome

Abstract:

The way in which DNA is uniquely folded in the nucleus into specific conformations enables and/or reflects cell-type specific interactions of active cis-regulatory elements, namely promoters and enhancers, to regulate specific programs of gene expression. The cohesin protein complex is a key player in the dynamic organisation of genome folding, orchestrating chromatin looping through a process known as loop extrusion. How this process is directed in a cell-type specific manner is currently...

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Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/100010269
Grant:
108861/Z/15/Z
Programme:
Genomic Medicine and Statistics
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2023-03-29

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