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Journal article

Clinical and endocrine responses to pituitary radiotherapy in pediatric Cushing's disease: an effective second-line treatment.

Abstract:

Transsphenoidal surgery (TSS) is considered first-line treatment for Cushing's disease (CD). Options for treatment of postoperative persisting hypercortisolemia are pituitary radiotherapy (RT), repeat TSS, or bilateral adrenalectomy. From 1983 to 2001, we treated 18 pediatric patients (age, 6.4-17.8 yr) with CD. All underwent TSS, and 11 were cured (postoperative serum cortisol, <50 nM). Seven (39%) had 0900-h serum cortisol of 269-900 nM during the immediate postoperative period (2-20 d),...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2002-021032

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
88
Issue:
1
Pages:
34-37
Publication date:
2003-01-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:5b12dcbe-fdc9-4382-be21-d23d026810af
Source identifiers:
138388
Local pid:
pubs:138388

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