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Targeting neuronal nitric oxide synthase with gene transfer to modulate cardiac autonomic function.

Abstract:

Microdomains of neuronal nitric oxide synthase (nNOS) are spatially localised within both autonomic neurons innervating the heart and post-junctional myocytes. This review examines the use of gene transfer to investigate the role of nNOS in cardiac autonomic control. Furthermore, it explores techniques that may be used to improve upon gene delivery to the cardiac autonomic nervous system, potentially allowing more specific delivery of genes to the target neurons/myocytes. This may involve mod...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Progress in biophysics and molecular biology
Volume:
84
Issue:
2-3
Pages:
321-344
Publication date:
2004-01-01
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
Source identifiers:
106325
Language:
English
Keywords:
Pubs id:
pubs:106325
UUID:
uuid:5b1205bb-fba5-4679-88ce-25302f1616bf
Local pid:
pubs:106325
Deposit date:
2013-11-16

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