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Cyclins and their related proteins in pituitary tumourigenesis.

Abstract:

Pituitary tumours are benign neoplasms that may cause major endocrine dysfunction. Transgenic disruption of the cell cycle machinery frequently leads to pituitary adenoma formation in animal models. The molecular analysis of human pituitary tumours has found various alterations in the expression of cell cycle regulators: cyclins, cyclin-dependent kinases and their inhibitors. There are also different mechanisms (e.g. hypermethylation, frameshift mutations, increased proteasome degradation) re...

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Publication status:
Published

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Publisher copy:
10.1016/j.mce.2010.03.017

Authors


Morris, DG More by this author
Korbonits, M More by this author
Grossman, AB More by this author
Journal:
Molecular and cellular endocrinology
Volume:
326
Issue:
1-2
Pages:
25-29
Publication date:
2010-09-05
DOI:
EISSN:
1872-8057
ISSN:
0303-7207
URN:
uuid:5b0ecf1e-c247-45b9-9c87-e39886032dd2
Source identifiers:
138477
Local pid:
pubs:138477

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