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Journal article

New horizons in hypoxia signaling pathways

Abstract:

Investigation into the regulation of the erythropoietin gene by oxygen led to the discovery of a process of direct oxygen sensing that transduces many cellular and systemic responses to hypoxia. The oxygen-sensitive signal is generated through the catalytic action of a series of 2-oxoglutarate-dependent oxygenases that regulate the transcription factor hypoxia-inducible factor (HIF) by the post-translational hydroxylation of specific amino acid residues. Here we review the implications of the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.yexcr.2017.03.008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Magdalen College
Role:
Author
Medical Research Council More from this funder
Cancer Research UK More from this funder
Ludwig Institute for Cancer Research More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Experimental Cell Research Journal website
Volume:
356
Pages:
116-121
Publication date:
2017-03-15
Acceptance date:
2017-03-07
DOI:
EISSN:
1090-2422
ISSN:
0014-4827
Keywords:
Pubs id:
pubs:685994
UUID:
uuid:5af7192a-7c53-4e32-bbf6-6354c4a9b909
Local pid:
pubs:685994
Deposit date:
2017-03-16

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