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A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue.

Abstract:

In this study we characterize a novel gene on human chromosome 9 and its translation product, PC3-secreted microprotein (PSMP). The gene contains three exons that encode a protein of 139 amino acid residues, including a predicted signal peptide of 36 residues. The molecule is homologous to beta-microseminoprotein (MSP), a protein of unknown function, secreted at high concentration by the prostate gland. These two proteins have only 23% sequence identity, but their common origin is revealed by...

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Publisher copy:
10.1515/bc.2007.032

Authors


Valtonen-André, C More by this author
Bjartell, A More by this author
Hellsten, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Härkönen, P More by this author
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Journal:
Biological chemistry
Volume:
388
Issue:
3
Pages:
289-295
Publication date:
2007-03-05
DOI:
EISSN:
1437-4315
ISSN:
1431-6730
URN:
uuid:5af6583c-e5a7-4cb2-8984-34c45b9cf317
Source identifiers:
365947
Local pid:
pubs:365947

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