- Abstract:
-
We have determined the structures of four complexes of HIV-1 reverse transcriptase with non-nucleoside inhibitors, three fully refined at high resolution. The highest resolution structure is of the RT-nevirapine complex which has an R-factor of 0.186 and a root-mean-square bond length deviation of 0.015 A for all data to 2.2 A. The structures reveal a common mode of binding for these chemically diverse compounds. The common features of binding are largely hydrophobic interactions and arise fr...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nsb0495-293
-
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- Journal:
- Nature structural biology
- Volume:
- 2
- Issue:
- 4
- Pages:
- 293-302
- Publication date:
- 1995-04-05
- DOI:
- ISSN:
-
1072-8368
- URN:
-
uuid:5ae3b5c8-54a4-4558-a8fb-4577661ea812
- Source identifiers:
-
13049
- Local pid:
- pubs:13049
- Language:
- English
- Keywords:
- Copyright date:
- 1995
Journal article
High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
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