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Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids.

Abstract:

Rhomboid is an intramembrane serine protease responsible for the proteolytic activation of Drosophila epidermal growth factor receptor (EGFR) ligands. Although nothing is known about the function of the approximately 100 currently known rhomboid genes conserved throughout evolution, a recent analysis suggests that a Rhomboid from the pathogenic bacterium Providencia stuartii is involved in the production of a quorum-sensing factor. This suggests that an intercellular signaling mechanism may h...

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Publication status:
Published

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Authors


Schlieper, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Current biology : CB
Volume:
12
Issue:
17
Pages:
1507-1512
Publication date:
2002-09-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:5adba377-d970-40b4-8a75-91faf17f250c
Source identifiers:
356083
Local pid:
pubs:356083

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