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Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man.

Abstract:

We examined the timing of apoptosis and the expression of the DNA repair proteins poly(ADP-ribose) polymerase (PARP) and Ku80 in sections of frontal and temporal lobes from patients who had suffered severe brain ischaemia due to a cardiac arrent. In situ end-labelling (ISEL) was used to detect apoptotic cells, and immunohistochemistry to assess PARP and Ku80. ISEL of scattered neurons and glia was demonstrable predominantly during the first 24 h after ischaemia. PARP and Ku80 immunoreactivity...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Neuroreport
Volume:
9
Issue:
6
Pages:
955-959
Publication date:
1998-04-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:5ad63119-507a-40f8-b545-23d878d70d2e
Source identifiers:
36188
Local pid:
pubs:36188

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