Safety and efficacy of galantamine in subjects with mild cognitive impairment.

Journal article

OBJECTIVE: To assess the safety of galantamine in subjects with mild cognitive impairment (MCI), the ability of galantamine to benefit cognition and global functioning in subjects with MCI, and the ability of galantamine to delay conversion to dementia. METHODS: In two studies, 2,048 subjects, 990 in Study 1 and 1,058 in Study 2, with a Clinical Dementia Rating (CDR) = 0.5, CDR memory score > or =0.5, without dementia were randomized to double-blind galantamine (16-24 mg/day) or placebo f...

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Authors: Winblad, B; Gauthier, S; Scinto, L; Feldman, H; Wilcock, G

• Publication status: Published
• Journal: Neurology
• Volume: 70
• Issue: 22
• Pages: 2024-2035
• Publication date: 2008-05-01
• DOI: 10.1212/01.wnl.0000303815.69777.26
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: Retrospective Studies; Double-Blind Method; Humans; Middle Aged; Aged; Alzheimer Disease; Cognition Disorders; Female; GAL-INT-11/18 Study Group; Galantamine; Aged, 80 and over; Cohort Studies; Male