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Genetic determinants of aromatase inhibitor-related arthralgia: The B-ABLE cohort study

Abstract:

A major side effect of aromatase inhibitor (AI) therapy is AI-related arthralgia (AIA), which often leads to therapy discontinuation. We aimed to identify genetic variants associated with AIA and therapy discontinuation in the first year of AI treatment. Our prospective cohort study included 343 postmenopausal women with early breast cancer starting AI therapy. Single nucleotide polymorphisms (SNPs) in candidate genes involved in estrogen and vitamin D signaling were selected. Univariate and ...

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Publisher copy:
10.1007/s10549-013-2638-3

Authors


Garcia-Giralt, N More by this author
Rodríguez-Sanz, M More by this author
Prieto-Alhambra, D More by this author
Servitja, S More by this author
Torres-Del Pliego, E More by this author
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Journal:
Breast Cancer Research and Treatment
Volume:
140
Issue:
2
Pages:
385-395
Publication date:
2013-07-05
DOI:
EISSN:
1573-7217
ISSN:
0167-6806
URN:
uuid:5acbcf82-993c-4c55-8003-2eb745cda565
Source identifiers:
419407
Local pid:
pubs:419407
Language:
English
Keywords:

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