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The effects of statin monotherapy on depressive symptoms: a systematic review and meta-analysis

Abstract:

Introduction Statins have been proposed as a strategy for treating depression, but their benefit in the absence of concurrent antidepressant treatment is unclear. This meta-analysis investigated the antidepressant effects of statin monotherapy in the general population. Methods We conducted a literature search of randomised controlled trials using any statin monotherapy versus any control condition for depressive symptoms. Our primary efficacy outcome was the mean value on any standardised s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jad.2022.05.113

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0001-5984-8696
Publisher:
Elsevier
Journal:
Journal of Affective Disorders More from this journal
Volume:
311
Pages:
336-343
Publication date:
2022-05-24
Acceptance date:
2022-05-19
DOI:
ISSN:
0165-0327
Language:
English
Keywords:
Pubs id:
1260110
Local pid:
pubs:1260110
Deposit date:
2022-05-19

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