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Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus.

Abstract:

Long-term potentiation (LTP) at hippocampal CA3-CA1 synapses is thought to be mediated, at least in part, by an increase in the postsynaptic surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) receptors induced by N-methyl-d-aspartate (NMDA) receptor activation. While this process was originally attributed to the regulated synaptic insertion of GluA1 (GluR-A) subunit-containing AMPA receptors, recent evidence suggests that regulated synaptic trafficking of ...

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Publication status:
Published

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Journal:
European journal of neuroscience
Volume:
29
Issue:
6
Pages:
1141-1152
Publication date:
2009-03-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Source identifiers:
16781

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