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Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

Abstract:
A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and desaturation of a (3S,5S)-carbapenam 2 to give a (5R)-carbapenem 1. All stereoisomers of 2 were synthesised and analysed as CarC substrates. The results imply that the (3S,5S)-carbapenam is an intermediate in carbapenem biosynthesis and that CarC is able to accept unnatural stereoisomers of its carbapenam substrate.
Publication status:
Published

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Publisher copy:
10.1002/cbic.200300908

Authors


Sleeman, MC More by this author
Chhabra, SR More by this author
Bycroft, BW More by this author
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Journal:
Chembiochem : a European journal of chemical biology
Volume:
5
Issue:
6
Pages:
879-882
Publication date:
2004-06-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:5ab3da31-cafd-400e-a2c7-fd929fbcadcc
Source identifiers:
32728
Local pid:
pubs:32728

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