Thesis icon

Thesis

Multi-omics analysis and modelling of T cell immunity and interferon signalling pathways for engineered T cell therapy

Abstract:

This thesis examines the nature of T cells through the lens of genomics. It delves into type I interferon (IFN)-mediated signalling in the tumour microenvironment (TME), focusing on the GMP-AMP synthase (cGAS)-stimulator of IFN genes (STING) pathway, and explores novel strategies to optimise T cell-based immunotherapy for triple-negative breast cancer (TNBC). In the first chapter, gene expression patterns of distinct T cell subtypes are studied to gain insight into the diverse T cell landscap...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-7913-2537

Contributors

Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Role:
Examiner
Institution:
University of Cambridge
Role:
Examiner
More from this funder
Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/100010269
Funding agency for:
Pavillet, CE
Grant:
215106/Z/18/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP