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MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.

Abstract:

Asthma, a chronic inflammatory disease of the lung, is characterized by reversible airway obstruction and airway hyperresponsiveness (AHR), and is associated with increased production of IgE and Th2-type cytokines (IL-4, IL-5, and IL-13). Development of inflammation within the asthmatic lung depends on MHC class II-restricted Ag presentation, leading to stimulation of CD4(+) T cells and cytokine generation. Conventional MHC class II pathways require both MHC-associated invariant chain (Ii) an...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.170.3.1473

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
170
Issue:
3
Pages:
1473-1480
Publication date:
2003-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5aa5f02f-5238-41d5-a702-1d1190d2229a
Source identifiers:
22045
Local pid:
pubs:22045

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