- Abstract:
-
Asthma, a chronic inflammatory disease of the lung, is characterized by reversible airway obstruction and airway hyperresponsiveness (AHR), and is associated with increased production of IgE and Th2-type cytokines (IL-4, IL-5, and IL-13). Development of inflammation within the asthmatic lung depends on MHC class II-restricted Ag presentation, leading to stimulation of CD4(+) T cells and cytokine generation. Conventional MHC class II pathways require both MHC-associated invariant chain (Ii) an...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.170.3.1473
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 170
- Issue:
- 3
- Pages:
- 1473-1480
- Publication date:
- 2003-02-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:5aa5f02f-5238-41d5-a702-1d1190d2229a
- Source identifiers:
-
22045
- Local pid:
- pubs:22045
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.
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