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Production of a high purity, C-tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions

Abstract:

Virus-like particles (VLPs) induce strong humoral and cellular responses and have formed the basis of some currently licensed vaccines. Here, we present the method used for the production of R21, a VLP-based anti-sporozoite malaria vaccine, under current Clinical Good Manufacturing Practice regulations (cGMP). Previous preclinical studies in BALB/c mice showed that R21 produced almost complete protection against sporozoite challenge with transgenic Plasmodium berghei parasites. He...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/bit.28181

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-6045-2522
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
106917/Z/15/Z
Publisher:
Wiley
Journal:
Biotechnology and Bioengineering More from this journal
Volume:
119
Issue:
10
Pages:
2784-2793
Publication date:
2022-07-22
Acceptance date:
2022-07-10
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
Pmid:
35822551
Language:
English
Keywords:
Pubs id:
1268072
Local pid:
pubs:1268072
Deposit date:
2022-12-12

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