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Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trial

Abstract:

BACKGROUND:
New antimalarials are needed for P. vivax and P. falciparum malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated P. vivax malaria.
METHODS AND FINDINGS:
This phase III randomized, double-blind, non-inferiority trial included five centers across Cambodia, Thailand, India, and Indonesia. In a double-dummy design, patients (aged >3-≤ 60 years) with microscopically confirmed P. vi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0014501

Authors


Poravuth, Y More by this author
Socheat, D More by this author
Rueangweerayut, R More by this author
Uthaisin, C More by this author
More by this author
Department:
Wolfson College
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
1
Pages:
e14501
Publication date:
2011-01-18
DOI:
EISSN:
1932-6203
Pubs id:
pubs:134467
URN:
uri:5aa00fbc-f9dd-48a3-b3d6-d9fce30d4206
UUID:
uuid:5aa00fbc-f9dd-48a3-b3d6-d9fce30d4206
Local pid:
pubs:134467

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