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Stimulators of tumour necrosis factor production released by damaged erythrocytes.

Abstract:

We sought to characterize factors released by sonicated human erythrocytes that stimulate peripheral blood mononuclear cells (PBMC) to release tumour necrosis factor-alpha (TNF). This response is not inhibited by polymyxin B, indicating that contaminating lipopolysaccharide (LPS) is not responsible. When erythrocyte lysates are fractionated by reverse-phase chromatography using a gradient of n-propanol on Sep-Pak C18 cartridges, the TNF-inducing activity elutes as a single peak. The erythrocy...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Immunology
Volume:
83
Issue:
2
Pages:
256-261
Publication date:
1994-10-01
EISSN:
1365-2567
ISSN:
0019-2805
Source identifiers:
35711
Language:
English
Keywords:
Pubs id:
pubs:35711
UUID:
uuid:5a984c72-68fa-4bfa-8e36-2a293cb3caa4
Local pid:
pubs:35711
Deposit date:
2012-12-19

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