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Thesis

Role of the collagen receptor DDR1 in epithelial morphogenesis and polarisation

Abstract:

During development of epithelial organs, epithelial cells collectively migrate and invade into their surroundings to form complex 3D structures, such as the tubular ducts and alveoli of the mammary gland. A prerequisite for coordinating such collective movement is apicobasal cell polarity. This polarity divides the plasma membrane of epithelial cells into an apical domain towards the lumen of structures and a basal domain facing the matrix. Polarity is essential for the functionality of ep...

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Institution:
University of Oxford
Oxford college:
St Catherine's College
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Role:
Supervisor
Kennedy Trust of Rheumatology More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:5a90207d-1d92-420e-b63b-f01d764575c6
Deposit date:
2018-03-17

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