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Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA.

Abstract:

Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), is widely used to study the role of histone acetylation in gene expression, since genes that use histone acetylation as a means of regulating expression may be up regulated when TSA is added. In this study, however, we show that TSA has an unexpected paradoxical effect leading to inhibition of NF-Y-associated histone acetyl transferase (HAT) activity and phosphorylation of the HAT, hGCN5. TSA treatment of cells resulted in dimi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Cancer letters
Volume:
166
Issue:
1
Pages:
55-64
Publication date:
2001-05-05
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:5a8a5697-1754-407e-8f58-97a8b2e28374
Source identifiers:
131328
Local pid:
pubs:131328

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