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A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.

Abstract:

TNF-alpha is a key factor in a variety of inflammatory diseases. This study examines the role of p38 MAPK in the regulation of TNF-alpha in primary human cells relevant to inflammation, e.g., macrophages and rheumatoid synovial cells. Using a dominant negative variant (D168A) of p38 MAPK and a kinase inhibitor, SB203580, we confirm in primary human macrophages that p38 MAPK regulates TNF-alpha production using a posttranscriptional mechanism requiring the 3' untranslated region of the gene. H...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
173
Issue:
11
Pages:
6928-6937
Publication date:
2004-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5a8741a2-ac79-4f99-8d52-cfb627849216
Source identifiers:
223497
Local pid:
pubs:223497

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