Journal article
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
- Abstract:
-
Gelatinase B is a matrix metalloproteinase (MMP-9) expressed under strict control by many cell types including neutrophils, monocytes, macrophages, and tumor cells. MMP-9 is a key mediator in the physiological maintenance of the extracellular matrix both in tissue remodeling and development, while uncontrolled enzyme activity contributes to pathologies such as cancer and inflammation. Neutrophils release MMP-9 from granules in response to IL-8 stimulation. Human MMP-9 has three potential N-li...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/bi001367j
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Bibliographic Details
- Journal:
- Biochemistry
- Volume:
- 39
- Issue:
- 51
- Pages:
- 15695-15704
- Publication date:
- 2000-12-01
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- Source identifiers:
-
100389
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:100389
- UUID:
-
uuid:5a863700-c2a1-40c3-b8a5-e92322435441
- Local pid:
- pubs:100389
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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