- Abstract:
- L-Deoxyrhamnojirimycin 1 does not inhibit naringinase significantly but 5-epi-L-deoxyrhamnojirimycin 2 is a potent inhibitor. Conversely, α-C-glycosides of 1 are good inhibitors of L-rhamnosidase whereas those of 2 are not. Intermediate azabicyclic lactones are likely to be of use for the incorporation of a number of trihydrocypipecolic acids into peptide libraries.
- Publication status:
- Published
- Publisher copy:
- 10.1016/0040-4039(96)01958-2
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- Journal:
- TETRAHEDRON LETTERS
- Volume:
- 37
- Issue:
- 47
- Pages:
- 8569-8572
- Publication date:
- 1996-11-18
- DOI:
- ISSN:
-
0040-4039
- URN:
-
uuid:5a79b807-33b1-4449-a2ab-a918d5ee5071
- Source identifiers:
-
45382
- Local pid:
- pubs:45382
- Language:
- English
- Copyright date:
- 1996
Journal article
Inhibition of naringinase (L-rhamnosidase) by piperidine analogues of L-rhamnose: Scaffolds for libraries incorporating trihydroxypipecolic acids
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