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Journal article

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.

Abstract:

Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte Ig-like receptor 1, CD85j, and LILRB1) is expressed on a wider range of immune cells including subsets of natural killer and T cells. Both ILTs contain immunoreceptor tyrosine-based inhibitory receptor motifs in their cytoplasmic tails that inhibit cellular responses by recruiting phosphatases suc...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1431057100

Authors


Shiroishi, M More by this author
Tsumoto, K More by this author
Shirakihara, Y More by this author
Colonna, M More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
15
Pages:
8856-8861
Publication date:
2003-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:5a73b58d-9e21-4563-ad6c-6263c2c5469e
Source identifiers:
25607
Local pid:
pubs:25607

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