- Abstract:
-
Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte Ig-like receptor 1, CD85j, and LILRB1) is expressed on a wider range of immune cells including subsets of natural killer and T cells. Both ILTs contain immunoreceptor tyrosine-based inhibitory receptor motifs in their cytoplasmic tails that inhibit cellular responses by recruiting phosphatases suc...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1431057100
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 100
- Issue:
- 15
- Pages:
- 8856-8861
- Publication date:
- 2003-07-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:5a73b58d-9e21-4563-ad6c-6263c2c5469e
- Source identifiers:
-
25607
- Local pid:
- pubs:25607
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
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