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Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.

Abstract:

We have applied the perforated patch whole-cell technique to beta cells within intact pancreatic islets to identify the current underlying the glucose-induced rhythmic firing of action potentials. Trains of depolarizations (to simulate glucose-induced electrical activity) resulted in the gradual (time constant: 2.3 s) development of a small (<0.8 nS) K(+) conductance. The current was dependent on Ca(2+) influx but unaffected by apamin and charybdotoxin, two blockers of Ca(2+)-activated K(+...

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Publisher copy:
10.1085/jgp.114.6.759

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Journal:
The Journal of general physiology
Volume:
114
Issue:
6
Pages:
759-770
Publication date:
1999-12-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:5a736ae9-8f2a-430d-b669-74e372f4c3bf
Source identifiers:
17623
Local pid:
pubs:17623

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