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High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end stage liver disease

Abstract:

The high replication and mutation rate of hepatitis C virus (HCV) results in a heterogeneous population of viral sequences in vivo. HCV replicates in the liver and infected hepatocytes occur as foci surrounded by uninfected cells that may promote compartmentalization of viral variants. Given recent reports showing interferon stimulated gene (ISG) expression in chronic hepatitis C, we hypothesized that local interferon responses may limit HCV replication and evolution.To investigate the spatia...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jhep.2016.07.048

Authors


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The Birmingham Children’s Hospital Research Foundation More from this funder
European Research Council More from this funder
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Funding agency for:
McKeating, J
Grant:
F3-2012–305578
More from this funder
Funding agency for:
McKeating, J
Grant:
F3-2012–305578
Publisher:
Elsevier Publisher's website
Journal:
Journal of hepatology Journal website
Volume:
66
Issue:
1
Pages:
28-38
Publication date:
2016-08-13
Acceptance date:
2016-07-29
DOI:
ISSN:
0168-8278 and 1600-0641
Pmid:
27531641
Source identifiers:
652133
Language:
English
Keywords:
Pubs id:
pubs:652133
UUID:
uuid:5a611dec-f937-42c0-a88a-835beca6d9b9
Local pid:
pubs:652133
Deposit date:
2017-01-29

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