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Journal article

Structural basis for the subunit assembly of the anaphase-promoting complex.

Abstract:

The anaphase-promoting complex or cyclosome (APC/C) is an unusually large E3 ubiquitin ligase responsible for regulating defined cell cycle transitions. Information on how its 13 constituent proteins are assembled, and how they interact with co-activators, substrates and regulatory proteins is limited. Here, we describe a recombinant expression system that allows the reconstitution of holo APC/C and its sub-complexes that, when combined with electron microscopy, mass spectrometry and docking ...

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Publication status:
Published

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Publisher copy:
10.1038/nature09756

Authors


Schreiber, A More by this author
Stengel, F More by this author
Enchev, RI More by this author
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Journal:
Nature
Volume:
470
Issue:
7333
Pages:
227-232
Publication date:
2011-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:5a5a24f2-4012-4cd8-a5b7-56253e8d9e63
Source identifiers:
120362
Local pid:
pubs:120362

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