- Abstract:
-
The anaphase-promoting complex or cyclosome (APC/C) is an unusually large E3 ubiquitin ligase responsible for regulating defined cell cycle transitions. Information on how its 13 constituent proteins are assembled, and how they interact with co-activators, substrates and regulatory proteins is limited. Here, we describe a recombinant expression system that allows the reconstitution of holo APC/C and its sub-complexes that, when combined with electron microscopy, mass spectrometry and docking ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nature09756
-
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- Journal:
- Nature
- Volume:
- 470
- Issue:
- 7333
- Pages:
- 227-232
- Publication date:
- 2011-02-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:5a5a24f2-4012-4cd8-a5b7-56253e8d9e63
- Source identifiers:
-
120362
- Local pid:
- pubs:120362
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Structural basis for the subunit assembly of the anaphase-promoting complex.
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