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Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array.

Abstract:

The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans. We used Affymetrix 500K genotyping data of KORA S3 cohort (n = 1,644; Southern-Germany) to address (i) SNP coverage in 160 BP candidate genes; (ii) the evidence for associations with BP traits in genome-wide and replication data, and haplotype analysis. In total, 160 gene regions (genic region+/-10 kb) cover...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0006034

Authors


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Alexander-von-Humboldt Foundation More from this funder
Estonian Ministry of Education and Science More from this funder
Howard Hughes Medical Institute More from this funder
Estonian Science Foundation More from this funder
Helmholtz Zentrum Munich More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
6
Pages:
Article: e6034
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:5a59470d-9e33-40d6-b6aa-afc470633737
Source identifiers:
105194
Local pid:
pubs:105194

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