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A refined open state of the glycine receptor obtained via molecular dynamics simulations

Abstract:

Abstract Fast neurotransmission is mediated by pentameric ligand-gated ion channels. Glycine receptors are chloride-selective members of this receptor family that mediate inhibitory synaptic transmission and are implicated in neurological disorders including autism and hyperekplexia. They have been structurally characterized by both X-ray crystallography and cryo electron microscopy studies, with the latter giving rise to what was proposed as a possible open state. However, recent work has qu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Lady Margaret Hall
Role:
Author
ORCID:
0000-0001-5100-8836
Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
28
Issue:
1
Pages:
130-139.e2
Publication date:
2019-11-18
Acceptance date:
2019-10-30
DOI:
Pubs id:
pubs:1024348
UUID:
uuid:5a568138-6854-495e-bfee-104774ec21a6
Source identifiers:
1024348
Local pid:
pubs:1024348
Keywords:

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