- Abstract:
-
Abstract Fast neurotransmission is mediated by pentameric ligand-gated ion channels. Glycine receptors are chloride-selective members of this receptor family that mediate inhibitory synaptic transmission and are implicated in neurological disorders including autism and hyperekplexia. They have been structurally characterized by both X-ray crystallography and cryo electron microscopy studies, with the latter giving rise to what was proposed as a possible open state. However, recent work has qu...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
- Publisher copy:
- 10.1016/j.str.2019.10.019
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 28
- Issue:
- 1
- Pages:
- 130-139.e2
- Publication date:
- 2019-11-18
- Acceptance date:
- 2019-10-30
- DOI:
- Pubs id:
-
pubs:1024348
- UUID:
-
uuid:5a568138-6854-495e-bfee-104774ec21a6
- Source identifiers:
-
1024348
- Local pid:
- pubs:1024348
- Keywords:
- Copyright holder:
- Name of copyright holder
- Copyright date:
- 2019
- Rights statement:
- © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license
- License:
- CC Attribution (CC BY)
Journal article
A refined open state of the glycine receptor obtained via molecular dynamics simulations
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