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A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide.

Abstract:

BACKGROUND: Several lines of evidence implicate 5-hydroxytryptamine (5-HT, serotonin) in the pathophysiology of mood disorders and suicide. However, it is unclear whether these conditions include morphological involvement of the dorsal raphe nucleus (DRN), the origin of most forebrain 5-HT innervation. METHOD: We used morphometric, immunohistochemical, and molecular methods to compare the DRN in post-mortem tissue of 50 subjects (13 controls, 14 major depressive disorder [MDD], 13 bipolar di...

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Publication status:
Published

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Publisher copy:
10.1016/j.jad.2011.10.043

Authors


Matthews, PR More by this author
Harrison, PJ More by this author
Journal:
Journal of affective disorders
Volume:
137
Issue:
1-3
Pages:
125-134
Publication date:
2012-03-05
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
URN:
uuid:5a4adb9e-0e02-4b81-b984-44a73b7551fb
Source identifiers:
216102
Local pid:
pubs:216102

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