- Abstract:
- We describe the cloning of a multifunctional folic acid synthesis (fas) gene from Pneumocystis carinii. The nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an Mr of 97,278. The predicted Fas protein has homology to two enzyme domains, dihydropteroate synthase and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, both of which are involved in folate synthesis, and at least one other region of unknown function.
- Publication status:
- Published
- Publisher copy:
- 10.1016/0378-1119(92)90378-3
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- Journal:
- Gene
- Volume:
- 112
- Issue:
- 2
- Pages:
- 213-218
- Publication date:
- 1992-03-05
- DOI:
- EISSN:
-
1879-0038
- ISSN:
-
0378-1119
- URN:
-
uuid:5a4207a4-d3d6-437e-904a-99e8f009b1d7
- Source identifiers:
-
72614
- Local pid:
- pubs:72614
- Copyright date:
- 1992
Journal article
The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase.
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