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Conformational constraints in nuclear DNA.

Abstract:

We have investigated DNA superstructure in a wide range of nuclei of higher cells by gently lysing cells to release structures that resemble nuclei but are depleted of nuclear proteins. The sedimentation properties of these structures, which we call nucleoids, have been examined in sucrose gradients containing the intercalating agent, ethidium. The sedimentation rate of nucleoids derived from the growing cells of mammals, birds, amphibians and insects varies in the manner characteristic of ci...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
22
Issue:
2
Pages:
287-302
Publication date:
1976-11-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:5a412d80-2339-4a0a-bd45-d559619aaa5a
Source identifiers:
9447
Local pid:
pubs:9447

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