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Journal article

Impact of schedule duration on head and neck radiotherapy: accelerated tumor repopulation versus compensatory mucosal proliferation.

Abstract:

PURPOSE: To determine how modelled maximum tumor control rates, achievable without exceeding mucositis tolerance (tcp(max-early)) vary with schedule duration for head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Using maximum-likelihood techniques, we have fitted a range of tcp models to two HNSCC datasets (Withers' and British Institute of Radiology [BIR]), characterizing the dependence of tcp on duration and equivalent dose in 2 Gy fractions (EQD(2)). Models likely to b...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
International journal of radiation oncology, biology, physics
Volume:
82
Issue:
2
Pages:
1021-1030
Publication date:
2012-02-01
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Source identifiers:
228639

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