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Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

Abstract:
Background: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. Principal Findings: Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs28... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0013795

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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La Direction Générale des Technologies de la Recherche et de l'Energie More from this funder
Communauté Française de Belgique More from this funder
Belgian Science Policy organization More from this funder
University of Ghent More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
5
Issue:
11
Pages:
Article: e13795
Publication date:
2009-01-01
DOI:
ISSN:
1932-6203
URN:
uuid:5a3f8ed2-7f36-4185-a1a1-b94861f1d138
Source identifiers:
575355
Local pid:
pubs:575355

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