- Abstract:
-
Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific expression modules that allow for stable expression of the gene of interest in cardiomyocytes. We therefore explored a new approach based on a genome-wide bioinformatics strategy that revealed novel cardiac-specific cis-acting regulatory modules (CS-CRMs). These transcriptional modules c...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.4mb)
-
- Publisher copy:
- 10.1038/mt.2014.178
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Molecular Therapy Journal website
- Volume:
- 23
- Issue:
- 1
- Pages:
- 43-52
- Publication date:
- 2014-10-07
- DOI:
- EISSN:
-
1525-0024
- ISSN:
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1525-0016
- URN:
-
uuid:5a3327aa-ff31-4a9b-9e75-0e51b35e5c4d
- Source identifiers:
-
565481
- Local pid:
- pubs:565481
- Language:
- English
- Keywords:
- Copyright holder:
- The American Society of Gene and Cell Therapy
- Copyright date:
- 2014
- Notes:
- © The American Society of Gene and Cell Therapy. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. This is the publisher's version of the article. The final version is available online from Nature Publishing Group at: [10.1038/mt.2014.178]
Journal article
Genome-wide computational analysis reveals cardiomyocyte-specific transcriptional Cis-regulatory motifs that enable efficient cardiac gene therapy.
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