Journal article
Genome-wide computational analysis reveals cardiomyocyte-specific transcriptional Cis-regulatory motifs that enable efficient cardiac gene therapy.
- Abstract:
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Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific expression modules that allow for stable expression of the gene of interest in cardiomyocytes. We therefore explored a new approach based on a genome-wide bioinformatics strategy that revealed novel cardiac-specific cis-acting regulatory modules (CS-CRMs). These transcriptional modules c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.4MB)
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- Publisher copy:
- 10.1038/mt.2014.178
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Funding
Geconcerteerde Onderzoeksactie
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Molecular Therapy Journal website
- Volume:
- 23
- Issue:
- 1
- Pages:
- 43-52
- Publication date:
- 2014-10-07
- DOI:
- EISSN:
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1525-0024
- ISSN:
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1525-0016
- Source identifiers:
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565481
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:565481
- UUID:
-
uuid:5a3327aa-ff31-4a9b-9e75-0e51b35e5c4d
- Local pid:
- pubs:565481
- Deposit date:
- 2016-01-22
Terms of use
- Copyright holder:
- The American Society of Gene and Cell Therapy
- Copyright date:
- 2014
- Notes:
- © The American Society of Gene and Cell Therapy. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. This is the publisher's version of the article. The final version is available online from Nature Publishing Group at: [10.1038/mt.2014.178]
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