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Genome-wide computational analysis reveals cardiomyocyte-specific transcriptional Cis-regulatory motifs that enable efficient cardiac gene therapy.

Abstract:

Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific expression modules that allow for stable expression of the gene of interest in cardiomyocytes. We therefore explored a new approach based on a genome-wide bioinformatics strategy that revealed novel cardiac-specific cis-acting regulatory modules (CS-CRMs). These transcriptional modules c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/mt.2014.178

Authors


Rincon, MY More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Keyaerts, M More by this author
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Grant:
7th Framework Programme: 222878, PERSIST
Geconcerteerde Onderzoeksactie More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Molecular Therapy Journal website
Volume:
23
Issue:
1
Pages:
43-52
Publication date:
2014-10-07
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:5a3327aa-ff31-4a9b-9e75-0e51b35e5c4d
Source identifiers:
565481
Local pid:
pubs:565481

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