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Journal article

Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides.

Abstract:

The chondroitin sulfate proteoglycan aggrecan forms link protein-stabilized complexes with hyaluronan (HA), via its N-terminal G1-domain, that provide cartilage with its load bearing properties. Similar aggregates (potentially containing new members of the link protein family), in which other chondroitin sulfate proteoglycans (i.e. versican, brevican, and neurocan) substitute for aggrecan, may contribute to the structural integrity of many other tissues including skin and brain. In this study...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m411297200

Authors


Seyfried, NT More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
The Journal of biological chemistry
Volume:
280
Issue:
7
Pages:
5435-5448
Publication date:
2005-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:5a290153-a795-41c2-9b69-03286be50806
Source identifiers:
112834
Local pid:
pubs:112834

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