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Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus.

Abstract:

Novel spatially restricted genetic manipulations can be used to assess contributions made by synaptic plasticity to learning and memory, not just selectively within the hippocampus, but even within specific hippocampal subfields. Here we generated genetically modified mice (NR1(deltaDG) mice) exhibiting complete loss of the NR1 subunit of the N-methyl-D-aspartate receptor specifically in the granule cells of the dentate gyrus. There was no evidence of any reduction in NR1 subunit levels in an...

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Publication status:
Published

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Journal:
The European journal of neuroscience
Volume:
25
Issue:
3
Pages:
837-846
Publication date:
2007-02-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:5a246b53-0679-404a-8a47-1531257f677b
Source identifiers:
13817
Local pid:
pubs:13817

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