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Journal article

Fetal and neonatal exposure to AZT and low-protein diet affects glucose homeostasis: a model with implications for AIDS prevention.

Abstract:

Zidovudine (AZT) lowers the perinatal transmission of HIV but can impair mitochondrial function by depleting mitochondrial DNA (mtDNA). AZT therapy and perinatal nutritional deprivation affect the body fat distribution, which influences glucose tolerance. We sought to model intrauterine exposure to AZT in humans to determine whether it interacts with low-protein diet (LPD) to impact on birth weight and glucose homeostasis in the offspring. Pregnant dams and their offspring were given AZT, an ...

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Publication status:
Published

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Publisher copy:
10.1152/ajpendo.00226.2005

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
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Journal:
American journal of physiology. Endocrinology and metabolism
Volume:
289
Issue:
6
Pages:
E1115-E1118
Publication date:
2005-12-05
DOI:
EISSN:
1522-1555
ISSN:
0193-1849
URN:
uuid:5a1f3969-1d63-4d06-a49a-cc60b0f4099f
Source identifiers:
248200
Local pid:
pubs:248200

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