- Abstract:
-
Zidovudine (AZT) lowers the perinatal transmission of HIV but can impair mitochondrial function by depleting mitochondrial DNA (mtDNA). AZT therapy and perinatal nutritional deprivation affect the body fat distribution, which influences glucose tolerance. We sought to model intrauterine exposure to AZT in humans to determine whether it interacts with low-protein diet (LPD) to impact on birth weight and glucose homeostasis in the offspring. Pregnant dams and their offspring were given AZT, an ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1152/ajpendo.00226.2005
-
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- Journal:
- American journal of physiology. Endocrinology and metabolism
- Volume:
- 289
- Issue:
- 6
- Pages:
- E1115-E1118
- Publication date:
- 2005-12-05
- DOI:
- EISSN:
-
1522-1555
- ISSN:
-
0193-1849
- URN:
-
uuid:5a1f3969-1d63-4d06-a49a-cc60b0f4099f
- Source identifiers:
-
248200
- Local pid:
- pubs:248200
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Fetal and neonatal exposure to AZT and low-protein diet affects glucose homeostasis: a model with implications for AIDS prevention.
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